We update the latest on the injury report on both sides of the South Carolina vs Clemson matchup. The South Carolina Gamecocks travel to Clemson, South Carolin

The No. 14 South Carolina Gamecocks (8-3) and the No. 12 Clemson Tigers (9-2) meet at Memorial Stadium Saturday. Kickoff is slated for noon ET (ESPN). Below, we look at South Carolina vs. Clemson odds from BetMGM Sportsbook’s college football odds before making our expert college football picks and predictions later in the week.

South Carolina hasn’t been favored against Clemson since 2013. Still, it’s a dramatic shift from the two- and three-touchdown Clemson spreads that dominated the series during the Tigers’ seven-game winning streak from 2015 to 2021.