A woman in need of a heart transplant was transported by police on a long, harrowing journey to a hospital in Ohio after getting stuck in the lake-effect storm that pummeled Chautauqua County this weekend,

A couple embarked on an approximately 260-mile drive just as a snowstorm struck over Thanksgiving weekend, New York State Police said, but their journey wasn’t holiday related. The pair from Rochester was en route to the Cleveland Clinic for the 64-year-old woman’s life-saving heart transplant, state troopers said.

New York State Troopers say they rescued a woman who was stranded in a snowstorm over the weekend as she was on her way to get a heart transplant.

The first big snowfall this season has blanketed parts of New York, Pennsylvania and Michigan over the weekend after Thanksgiving.

The first big snowfall of the season blanketed parts of New York, Pennsylvania and Michigan during the hectic U.S. holiday travel and shopping weekend, with numbing cold and heavy snow forecast to persist through the early part of the week and cause hazards in the Great Lakes,

Near Buffalo, between 10 and 20 inches of lake effect snow is expected by the end of Sunday, according to the Weather Service. The southern part of Erie County, along with Wyoming, Chautauqua and Cattaraugus counties, are predicted to see 2 to 4 feet of snow by Monday night.

Portions of Interstate 90 in New York state has reopened to passenger vehicles as the Great Lakes region continues to be pummeled by a record-breaking lake-effect snow event that has dumped several feet of snow across the area.

Sunday night’s game between the San Francisco 49ers and Bills is still on but the weather outside the stadium in Buffalo suburb Orchard Parch is frightful. Still snowing in Orchard Park. #GoBills | #BillsMafia pic.

The Thanksgiving week of NFL action could see a snowy matchup on "Sunday Night Football." After games on both Thanksgiving and Black Friday, the NFL caps off the Sunday slate with the Buffalo Bills hosting the San Francisco 49ers.

The Buffalo Bills' first snow game of the season comes in an important showdown Sunday night against the San Francisco 49ers.