Playing in overtime in the season finale against the Falcons, Winston threw a pass on the first and only OT play from scrimmage and the ball landed in the arms of Atlanta linebacker Deion Jones, who took it 27 yards the other way to give his team a 28-22 win.

Ja'Quan McMillian had the biggest pick-six as it came in the final minutes of the game. The Broncos were up 34-32 and the Browns were driving down the field trying to get in field goal position to win the game. Winston made a mistake, and McMillian took advantage of it as he took the pick to the house, and that sealed the win for the Broncos.

Jameis Winston set a Browns record for passing yards and threw four touchdowns against the Broncos, but two pick-sixes soured his night.

When Jameis Winston is your starting quarterback, every week is a roller coaster ride and the Cleveland Browns got the full Jameis Winston experience on Monday night during a wild 41-32 loss in Denver.

It wasn't the best night for Browns quarterback Jameis Winston, who completed 34 of his 58 passes for 497 yards and four touchdowns, but his three interceptions (including two that were returned for touchdowns) proved consequential in the outcome.

Browns quarterback Jameis Winston makes unique history with a four-touchdown, three-interception game in Week 13 against the Broncos