With its 35-10 loss at Buffalo on Sunday night, the 49ers have now dropped three straight to sink to 5-7 on the season. The blowout loss also marked the first time since 2015 and just the fourth time in franchise history that San Francisco has lost back-to-back games by 25 points or more.

San Francisco 49ers quarterback Brock Purdy feels sorry for the brutal injury suffered by Christian McCaffrey.

We're live with the Week 13 edition of "Sunday Night Football" as the Buffalo Bills play host to the San Francisco 49ers to cap what has been a wild Thanksgiving weekend of NFL games. San Francisco enters this game incredibly banged up,

NFL Week 13 closes with Sunday Night Football as the San Francisco 49ers visit Highmark Stadium and the Buffalo Bills. Time and how to watch.

SportsLine's model has simulated San Francisco vs. Buffalo on Sunday Night Football 10,000 times and revealed its SNF picks and NFL predictions

The 2024 NFL Week 13 games end with Sunday Night Football as the Buffalo Bills host the San Francisco 49ers. NFL TV schedule, time and how to watch.

San Francisco 49ers quarterback Brock Purdy is expected to play Sunday night against the Buffalo Bills, according to ESPN's Adam Schefter. Purdy was

The Miami Dolphins lost Thursday night in Green Bay and officially need help to get into the playoffs. Help, though, is not what they got during the NFL’s Week 13 Sunday slate. Wins by, first and foremost,

How will the Eagles fare in a playoff atmosphere? They passed a test on Sunday with perhaps their most impressive win. And their cost-effective defense played a big role.