San Francisco has put up a combined 27 points the past two weeks and faces a Bills defense great at generating pressure with just the front four. Buffalo is Top 10 in EPA allowed per pay and very stingy against the run, sitting seventh in run-stop win rate at ESPN and No. 9 in opponent success rate per handoff.

Before locking in any Packers vs. 49ers picks, you'll want to see the NFL predictions and betting advice from the proven computer simulation model at SportsLine. The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 ...

Just when it looked like the defending NFC champions were getting their act together after a slow start, there go the 49ers.

How high did the Broncos rise and how far did the 49ers fall in our Week 13 Power Rankings? Plus, we look at every team's FPI rankings.

Taking care of expected business during the bye week would have been a head start, though. New York Jets (3-8, Bye Week) Woody Johnson took the bye week literally and said "Bye" to GM Joe Douglas, who was a master at drafting talented players.

After the Green Bay Packers moved to 8-3, things are looking rosy as far as playoff qualification goes. Here's what to know.

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Here’s a look at the NFC playoff picture following the Green Bay Packers’ blowout victory over the San Francisco 49ers.