A picturesque setting of snow was the perfect backdrop for a Buffalo Bills team that has now won its fifth straight AFC East title.
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The Chiefs were the first team to clinch an NFL playoff berth, but the Bills can one-up them by sealing the AFC East with a win over the 49ers.
San Francisco running back Christian McCaffrey suffered a knee injury that coach Kyle Shanahan described as “potentially” season-ending in the 49ers’ 35-10 loss to the Buffalo Bills on Sunday night.
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San Francisco 49ers at Buffalo Bills: Predictions, picks and odds for NFL Week 13 game
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Sunday Night Football prediction, NFL odds, line, spread: 49ers vs. Bills picks from Niners expert on 25-6 run
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49ers vs. Bills Best NFL Prop Bets for Sunday Night Football in NFL Week 13
Josh Allen expertly navigated snow-topped turf, finding the end zone in a multitude of fashions and even receiving credit for catching his own touchdown pass in a Buffalo Bills thrashing of the San Francisco 49ers.
The San Francisco 49ers' losses to the Green Bay Packers and Buffalo Bills mark the worst two-game stretch by a defending conference champion since the 1970 merger.
How to watch NFL Week 14 games on television this week, including schedule, dates, times, matchups, TV channels, streaming information for every game.
SportsLine's model has simulated San Francisco vs. Buffalo on Sunday Night Football 10,000 times and revealed its SNF picks and NFL predictions
Here's where the 49ers sit in the 2025 NFL Draft order after San Francisco's 35-10 blowout loss to the Buffalo Bills on Sunday at Highmark Stadium.
San Francisco 49ers quarterback Brock Purdy is expected to play Sunday night against the Buffalo Bills, according to ESPN's Adam Schefter. Purdy was
Happy Holidays, football fans! The Bills kicked off the holiday season with a fun win over the 49ers in the snow on Sunday night.
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