Providing the betting odds and our preview and prediction for the star-studded matchup between the San Francisco 49ers and ...

The San Francisco 49ers didn’t have many changes to their Thursday practice participation report.

In a season where running backs are thriving in the NFL, the 49ers hope to get Christian McCaffrey back on track.

Christian McCaffrey is averaging a mere 3.5 yards per carry this season since he returned from bilateral Achilles tendonitis.

Christian McCaffrey is deadly serious about his 9-to-5 job — head coach Kyle Shanahan calls him “a psycho in the best way ...

Since returning from an Achilles tendinitis issue, Christian McCaffrey has dominated the San Francisco 49ers' backfield, ...

The San Francisco 49ers are up against the Buffalo Bills in Week 13. The 49ers have dealt with an array of injuries this ...

San Francisco 49ers head coach Kyle Shanahan was strong in defending Christian McCaffrey from criticism following his poor ...

One thing does not change, though. The defending NFC champion 49ers are 5-6 and they need to get on a heater - which will be ...

Support is pouring in for a young Packers fan who was denied an autographed football he won last weekend at a 49ers party.

The 49ers’ situation could grow even more dire if Brock Purdy isn’t ready for Sunday’s must-win matchup against the Buffalo ...

Brock Purdy threw one short pass in the open portion of practice for the San Francisco 49ers as he remains slowed by an ...