San Francisco 49ers quarterback and Iowa State alum Brock Purdy is showing promising signs after being injured on Nov. 17.

People are beginning to lose confidence in Kyle Shanahan. The latest person to take him to task is former NFL player and ...

A former NFL star has ripped into San Francisco 49ers head coach Kyle Shanahan as the Los Angeles Rams' fierce rivals ...

The 49ers keep losing key players to injuries. The latest one who could miss time is rookie right guard Dominick Puni. He ...

For more than a century, Times Union photographers have been documenting the Capital Region’s fascinating people, places and pivotal moments. About Contact Services Account ...

The San Francisco 49ers have struggled to get their offense going recently, and that includes wide receiver Deebo Samuel.

Next up for Bills, 9-2, are the beleaguered San Francisco 49ers, 5-6, who limp into Highmark Stadium on Sunday night riding a ...

San Francisco quarterback Brock Purdy took part in some light throwing on Monday after missing his first career game because ...

After an embarrassing 38-10 loss at the Green Bay Packers on Sunday, the San Francisco 49ers are running out of room for ...

The 49ers have a 17% chance of making the playoffs and have one of the toughest remaining schedules -- all while injuries ...

Week 12 and its plethora of bye weeks is behind us. Here are 16 players to start or sit in your Week 13 fantasy football ...

The Buffalo Bills' upcoming opponent, the San Francisco 49ers, provided a big injury update for their starting quarterback ...