San Francisco 49ers quarterback and Iowa State alum Brock Purdy is showing promising signs after being injured on Nov. 17.

The San Francisco 49ers fell to an incomprehensible 5-6 with their Week 12 loss to the Green Bay Packers, and while the 49ers ...

San Francisco 49ers head coach Kyle Shanahan spoke with reporters via a conference call on Monday, providing several injury ...

People are beginning to lose confidence in Kyle Shanahan. The latest person to take him to task is former NFL player and ...

For more than a century, Times Union photographers have been documenting the Capital Region’s fascinating people, places and pivotal moments. About Contact Services Account ...

The San Francisco 49ers have struggled to get their offense going recently, and that includes wide receiver Deebo Samuel.

From Jordan Addison to D.J. Moore to Patrick Mahomes, a deep dive into which players are due for regression in Week 13 and ...

Next up for Bills, 9-2, are the beleaguered San Francisco 49ers, 5-6, who limp into Highmark Stadium on Sunday night riding a ...

San Francisco quarterback Brock Purdy took part in some light throwing on Monday after missing his first career game because ...

After an embarrassing 38-10 loss at the Green Bay Packers on Sunday, the San Francisco 49ers are running out of room for ...

The Buffalo Bills' upcoming opponent, the San Francisco 49ers, provided a big injury update for their starting quarterback ...

The 49ers are taking stock of their injury situation but could be getting some key players back for Buffalo game.