The 28-year-old took to social media on Wednesday to share a heartfelt message for 49ers fans after his injury-plagued ...

San Francisco 49ers running back Christian McCaffrey was placed on injured reserve for the second time this season after ...

San Francisco 49ers running back Christian McCaffrey has spoken out after being placed on injured reserve with yet another ...

Christian McCaffrey suffered a PCL injury in the 49ers' Week 13 loss to the Bills. He addressed the injury on social media ...

Christian McCaffrey's injury-ridden season took another unfortunate turn when the star running back went down with another ...

McCaffrey immediately checked himself out of the game and ran right into the medical tent. The 49ers star RB missed the ...

McCaffrey should be fine long term, though it's hard to say whether he'd be able to play again this season if the 49ers made ...

The San Francisco 49ers on Wednesday continued adjusting to life without running backs Christian McCaffrey and Jordan Mason.

Running back Christian McCaffrey is on injured reserve for the second time this season, but San Francisco 49ers coach Kyle ...

McCaffrey was initially said to be out at least six weeks — with five weeks left in the season. Niners head coach Kyle ...

Taking to social media to address the situation head-on, McCaffrey delivered a bittersweet statement to his fans on Instagram ...

Isaac Guerendo didn’t start in college until his final game.. He starts at running back for the 49ers Sunday against Chicago.