San Francisco 49ers running back Christian McCaffrey was placed on injured reserve for the second time this season after ...

Isaac Guerendo didn’t start in college until his final game.. He starts at running back for the 49ers Sunday against Chicago.

The 28-year-old took to social media on Wednesday to share a heartfelt message for 49ers fans after his injury-plagued ...

The San Francisco 49ers officially placed Christian McCaffrey on Injured Reserve on Tuesday. McCaffrey's 2024 season is done ...

San Francisco 49ers running back Christian McCaffrey has spoken out after being placed on injured reserve with yet another ...

Christian McCaffrey suffered a PCL injury in the 49ers' Week 13 loss to the Bills. He addressed the injury on social media ...

The San Francisco 49ers are not in a good place right now, and that includes the status of Christian McCaffrey. The All-Pro ...

McCaffrey should be fine long term, though it's hard to say whether he'd be able to play again this season if the 49ers made ...

Christian McCaffrey's injury-ridden season took another unfortunate turn when the star running back went down with another ...

The San Francisco 49ers on Wednesday continued adjusting to life without running backs Christian McCaffrey and Jordan Mason.

Former Wisconsin Badgers running back Isaac Guerendo is in line to serve as the San Francisco 49ers starting running back for ...

Taking to social media to address the situation head-on, McCaffrey delivered a bittersweet statement to his fans on Instagram ...