George Kittle will lead the San Francisco 49ers into their matchup versus the Buffalo Bills at Highmark Stadium on Sunday at ...

NFL Week 13 odds, picks, predictions, TV and streaming information for Sunday Night Football game between the San Francisco ...

San Francisco played without four key players - quarterback Brock Purdy, left tackle Trent Williams, defensive end Nick Bosa ...

Here’s how you can watch, stream and listen to the game. Bills vs. 49ers will air on NBC. Mike Tirico will be on play-by-play ...

This Sean McDermott stat should give Buffalo Bills fans confidence entering their Week 13 matchup with the San Francisco ...

San Francisco 49ers head coach Kyle Shanahan told reporters that quarterback Brock Purdy did some light throwing without any ...

Take a look at the 16 games on the Week 13 NFL schedule this week, starting with three games on Thanksgiving ( Chicago Bears ...

The San Francisco 49ers and Buffalo Bills will clash on "Sunday Night Football." Here's how to watch the Week 13 NFL game ...

The 49ers have been careful not to open practice windows for any of their players too early. With that in mind, if everything ...

Next up for Bills, 9-2, are the beleaguered San Francisco 49ers, 5-6, who limp into Highmark Stadium on Sunday night riding a ...

The Bills return from their bye week with a tough test on Sunday Night Football. Here's a look ahead to the matchup.

The Buffalo Bills' upcoming opponent, the San Francisco 49ers, provided a big injury update for their starting quarterback ...