San Francisco 49ers running back Christian McCaffrey is in Buffalo for a Week 13 contest against the Bills on Sunday night.

Running back Christian McCaffrey refuses to buy into the doom and gloom surrounding the San Francisco 49ers since two ...

Head coach Kyle Shanahan shared the final injury report on QB Brock Purdy, DL Nick Bosa and others and discussed the team's ...

There’s a running back renaissance taking place in the NFL and Christian McCaffrey has yet to take part in it.

One thing does not change, though. The defending NFC champion 49ers are 5-6 and they need to get on a heater - which will be ...

The AFC East-leading Buffalo Bills return from their bye week to host the inconsistent San Francisco 49ers on Sunday night ...

Providing the betting odds and our preview and prediction for the star-studded matchup between the San Francisco 49ers and ...

Watch Matt Maiocco's full "Game Plan" interview with John Lynch at 9:30 p.m. PT Friday on NBC Sports Bay Area. SANTA CLARA — ...

Building winning Fantasy football picks requires a full understanding of Fantasy football injuries and Fantasy football ...

But even when most or all of those Niners took the field this year, closing out games has been a glaring weakness for a team expected to compete for the NFC. A loss to Seattle in Week 11 marked the ...

The San Francisco 49ers are up against the Buffalo Bills in Week 13. The 49ers have dealt with an array of injuries this ...

San Francisco 49ers head coach Kyle Shanahan was strong in defending Christian McCaffrey from criticism following his poor ...