The San Francisco 49ers running back has sustained a posterior cruciate ligament (PCL) injury, head coach Kyle Shanahan ...

After sparking the 49ers with a handful of impressive runs, Christian McCaffrey looked like himself early in the game against ...

McCaffrey immediately checked himself out of the game and ran right into the medical tent. The 49ers star RB missed the ...

San Francisco 49ers running back Christian McCaffrey suffered a knee injury and limped to the locker room in the second ...

The 49ers’ third straight defeat came in 35-10 fashion to the AFC East-clinching Buffalo Bills amid a snowstorm at Highmark ...

The swagger is officially gone from this season's 49ers after another miserable outing in a 35-10 loss in Buffalo.

On a snowy night in Orchard Park, N.Y., the Buffalo Bills clinched the AFC East title with a dominant win over the San ...

Christian McCaffrey was having a resurgent game against the Buffalo Bills. He finally looked like the player who was supposed ...

Christian McCaffrey pulled up limping after taking a pitch early in their game against the Bills on Sunday night.

San Francisco 49ers running back Christian McCaffrey was running wild against the Buffalo Bills on Sunday Night Football.

The 49ers season is still trending down and now they're searching for answers on if they can get back on track.