The highest snow accumulations are expected east of Lake Ontario, where some isolated areas could get up to 60 inches of lake effect snow early in the week.

Post-Thanksgiving travel is expected to be impacted by winter weather and frigid temperatures as millions of people across the U.S. pack up and head home after the holiday.

Tuesday and Wednesday should be the busiest days on the road, and disruptive weather could occur both days before Thanksgiving, AccuWeather says.

An arctic blast of severe cold and snow is creating hazardous conditions across the Great Lakes region over the next two days, according to the US Weather Prediction Center, potentially disrupting the plans of millions traveling the roads and skies.

An Arctic blast brought snow, frost and dangerously cold winds to the northern Plains, Midwest and Great Lakes, creating difficult travel conditions on one of the busiest travel days of the year, as millions of Americans head home from their Thanksgiving destinations.