Providing the betting odds and our preview and prediction for the star-studded matchup between the San Francisco 49ers and ...

In a season where running backs are thriving in the NFL, the 49ers hope to get Christian McCaffrey back on track.

The San Francisco 49ers are up against the Buffalo Bills in Week 13. The 49ers have dealt with an array of injuries this ...

San Francisco 49ers head coach Kyle Shanahan was strong in defending Christian McCaffrey from criticism following his poor ...

Watch Matt Maiocco's full "Game Plan" interview with John Lynch at 9:30 p.m. PT Friday on NBC Sports Bay Area. SANTA CLARA — ...

The San Francisco 49ers got superstar RB Christian McCaffrey back ahead of a Week 13 matchup with the Buffalo Bills.

One thing does not change, though. The defending NFC champion 49ers are 5-6 and they need to get on a heater - which will be ...

Christian McCaffrey is averaging a mere 3.5 yards per carry this season since he returned from bilateral Achilles tendonitis. Here's what McCaffrey said about h ...

The AFC East-leading Buffalo Bills return from their bye week to host the inconsistent San Francisco 49ers on Sunday night ...

The 49ers’ situation could grow even more dire if Brock Purdy isn’t ready for Sunday’s must-win matchup against the Buffalo ...

But even when most or all of those Niners took the field this year, closing out games has been a glaring weakness for a team expected to compete for the NFC. A loss to Seattle in Week 11 marked the ...

Jordan Love's fiancee, Ronika Stone's father, Ron Smith, played for the NFL, too. He retired in 2006, years before Love would ...