McCaffrey immediately checked himself out of the game and ran right into the medical tent. The 49ers star RB missed the ...

Christian McCaffrey suffered a PCL injury in the 49ers' Week 13 loss to the Bills. He addressed the injury on social media ...

Isaac Guerendo didn’t start in college until his final game.. He starts at running back for the 49ers Sunday against Chicago.

In 40 other games at Wisconsin and Louisville, Guerendo played in a shared backfield –something he’s done with the 49ers this ...

The 28-year-old took to social media on Wednesday to share a heartfelt message for 49ers fans after his injury-plagued ...

Taking to social media to address the situation head-on, McCaffrey delivered a bittersweet statement to his fans on Instagram ...

McCaffrey was initially said to be out at least six weeks — with five weeks left in the season. Niners head coach Kyle ...

San Francisco 49ers running back Christian McCaffrey was placed on injured reserve for the second time this season after ...

Head coach Kyle Shanahan reflected on the team's performance against the Bills, previewed the upcoming Week 14 matchup ...

Isaac Guerendo will make his first NFL start on Sunday as the injury-depleted San Francisco 49ers face the Chicago Bears. The ...

San Francisco 49ers running back Christian McCaffrey has spoken out after being placed on injured reserve with yet another ...

On Sunday night against the Buffalo Bills, star running back Christian McCaffrey suffered a knee injury that may cost him the ...