Running back Christian McCaffrey is on injured reserve for the second time this season, but San Francisco 49ers coach Kyle ...

Christian McCaffrey's injury-ridden season took another unfortunate turn when the star running back went down with another ...

Christian McCaffrey practiced little and played less this season, seeing action in four games with 65 touches. He is out for the season with his knee injury that will require a six-week recovery.

McCaffrey immediately checked himself out of the game and ran right into the medical tent. The 49ers star RB missed the ...

San Francisco 49ers star Christian McCaffrey recently took to social media to send fans and supporters a message about his ...

San Francisco 49ers running back Christian McCaffrey scared NFL fans across the country this Wednesday with a heartfelt ...

Isaac Guerendo didn’t start in college until his final game.. He starts at running back for the 49ers Sunday against Chicago.

McCaffrey appeared to have finally gotten untracked against ... and Guerendo became the lead runner for a team that is sixth ...

Christian McCaffrey suffered a torn PCL in the San Francisco 49ers' 35-10 Week 13 loss to the Buffalo Bills. The injury is ...

The running back position took a massive hit in Week 13 for the San Francisco 49ers. Christian McCaffrey (knee) and Jordan Mason (ankle) sustained injuries in t ...

On Wednesday, McCaffrey, the former Carolina Panthers star, shared his initial thoughts on the 2024 NFL season following his ...

Isaac Guerendo will make his first NFL start on Sunday as the injury-depleted San Francisco 49ers face the Chicago Bears. The ...