The Buffalo Bills are fresh off of their bye week heading into a Sunday Night Football matchup with the San Francisco 49ers, ...

NFL Week 13 odds, picks, predictions, TV and streaming information for Sunday Night Football game between the San Francisco ...

San Francisco played without four key players - quarterback Brock Purdy, left tackle Trent Williams, defensive end Nick Bosa ...

San Francisco 49ers head coach Kyle Shanahan told reporters that quarterback Brock Purdy did some light throwing without any ...

The San Francisco 49ers and Buffalo Bills will clash on "Sunday Night Football." Here's how to watch the Week 13 NFL game ...

The 49ers have been careful not to open practice windows for any of their players too early. With that in mind, if everything ...

The Bills return from their bye week with a tough test on Sunday Night Football. Here's a look ahead to the matchup.

Next up for Bills, 9-2, are the beleaguered San Francisco 49ers, 5-6, who limp into Highmark Stadium on Sunday night riding a ...

San Francisco has put up a combined 27 points the past two weeks and faces a Bills defense great at generating pressure with ...

The Buffalo Bills' upcoming opponent, the San Francisco 49ers, provided a big injury update for their starting quarterback ...

The San Francisco 49ers will hold three full practices this week as they prepare for their Week 13 matchup against the ...

San Francisco 49ers quarterback and Iowa State alum Brock Purdy is showing promising signs after being injured on Nov. 17.